Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect
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چکیده
منابع مشابه
role of cultural iran in promotion of multilaieralism in central asia and caucasus
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15 صفحه اولLack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Connexin32 (Cx32) is the major gap junction forming protein in liver. We have recently shown that hepatocarcinogenesis is strongly enhanced in mice deficient in Cx32, demonstrating that lack of functional Cx32 accelerates liver tumorigenesis. Many tumor-promoting agents, including phenobarbital, block gap junctional intercellular communication in vitro, and it has been suggested that this effec...
متن کاملEffect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats.
Hepatocarcinogenesis was induced in Sprague Dawley rats by injecting diethylnitrosamine (DENA); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. Concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. Noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated ...
متن کاملModifying role of partial hepatectomy and gonadectomy in ethylnitrosourea-induced hepatocarcinogenesis.
The modifying effect of partial hepatectomy and gonadectomy upon carcinogenesis in general and hepatocarcinogenesis in particular has been evaluated in 6-week-old C57BL/6J x C3HeB/FeJ F, mice. Ethylnitrosourea (60 ftg/g body weight) was administered once after sham hepatectomy or 48 hr following partial hepatectomy at which time DMA synthesis in the regenerating liver was 30-fold higher than in...
متن کاملMechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
Phenobarbital (PB), a classical rodent hepatopromoter, remarkably enhances hepatocarcinogenesis initiated by diethylnitrosamine (DEN) in adult B6C3F1 mice. However, it is also known to strongly inhibit liver tumor development in the B6C3F1 mice initiated with DEN in their infancy. The present study aimed to elucidate the unknown biological mechanisms for this paradoxical, inhibitory effect of P...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1983
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1983.82